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S1P exerts its effects through binding to five G-protein coupled receptors (S1PR1-5) with variable tissue distribution: S1PR13 are ubiquitously expressed, S1PR4 is predominantly located in lymphoid tissue and lungs, while S1PR5 is primarily expressed in the central nervous system and spleen

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No oxidation targets: The copper-catalyzed oxidation concern requires cysteine or methionine residues